Publikationen

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Publikationen 2013

  • European Society of Cardiology, Committee for Education, Authors/Task Force Members:, Gillebert T.C., Brooks N., Fontes-Carvalho R., Fras Z., Gueret P., Lopez-Sendon J., Salvador M.J., van den Brink R.B.A., Smiseth O.A., Observer on behalf of the UEMS (Cardiology Section):, Griebenow R., Review Coordinators:, Kearney P., Vahanian A., Contributors and reviewers:, Bauersachs J., Bax J., Burri H., Caforio A.L.P., Calvo F., Charron P., Ertl G., Flachskampf F., Giannuzzi P., Gibbs S., Gonçalves L., González-Juanatey J.R., Hall J., Herpin D., Iaccarino G., Iung B., Kitsiou A., Lancellotti P., McDonough T., Monsuez J.J., Nuñez I.J., Plein S., Porta-Sánchez A., Priori S., Price S., Regitz-Zagrosek V., Reiner Z., Ruilope L.M., Schmid J.P., Sirnes P.A., Sousa-Ouva M., Stepinska J., Szymanski C., Taggart D., Tendera M., Tokgözoglu L., Trindade P., Zeppenfeld K., ESC staff:, Joubert L. & Carrera C.: ESC Core Curriculum for the General Cardiologist (2013). Eur Heart J 2013;34:2381-411
  • Kaczmarek I., Meiser B., Beiras-Fernandez A., Guethoff S., Überfuhr P., Angele M., Seeland U., Hagl C., Reichart B. & Eifert S.: Gender does matter: gender-specific outcome analysis of 67,855 heart transplants. Thorac Cardiov Surg 2013;61:29-36
  • Lleo A., Oertelt-Prigione S., Bianchi I., Caliari L., Finelli P., Miozzo M., Lazzari R., Floreani A., Donato F., Colombo M., Gershwin M.E., Podda M. & Invernizzi P.: Y chromosome loss in male patients with primary biliary cirrhosis. J Autoimmun 2013;41:87-91
  • Lossnitzer N., Herzog W., Störk S., Wild B., Müller-Tasch T., Lehmkuhl E., Zugck C., Regitz-Zagrosek V., Pankuweit S., Maisch B., Ertl G., Gelbrich G., Angermann C.E. & Competence Network Heart Failure: Incidence rates and predictors of major and minor depression in patients with heart failure. Int J Cardiol 2013;167:502-7
  • Nguyen B.T., Kararigas G. & Jarry H.: Dose-dependent effects of a genistein-enriched diet in the heart of ovariectomized mice. Genes Nutr 2013;8:383-90
  • Oertelt-Prigione S., Kendel F., Kaltenbach M., Hetzer R., Regitz-Zagrosek V. & Baretti R.: Detection of gender differences in incomplete revascularization after coronary artery bypass surgery varies with classification technique. Biomed Res Int 2013;2013:108475
  • Queirós A.M., Eschen C., Fliegner D., Kararigas G., Dworatzek E., Westphal C., Sanchez Ruderisch H. & Regitz-Zagrosek V.: Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart. Int J Cardiol 2013;169:331-8
  • Regitz-Zagrosek V., Dworatzek E., Kintscher U. & Dragun D.: Sex and sex hormone-dependent cardiovascular stress responses. Hypertension 2013;61:270-7
  • Westphal C., Spallek B., Konkel A., Marko L., Qadri F., DeGraff L.M., Schubert C., Bradbury J.A., Regitz-Zagrosek V., Falck J.R., Zeldin D.C., Müller D.N., Schunck W.H. & Fischer R.: CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy. PLoS ONE 2013;8:e73490

Publikationen 2012

  • Benz V., Bloch M., Wardat S., Böhm C., Maurer L., Mahmoodzadeh S., Wiedmer P., Spranger J., Foryst-Ludwig A. & Kintscher U.: Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis. PLoS ONE 2012;7:e37794
  • Biermann J., Neumann T., Angermann C.E., Erbel R., Maisch B., Pittrow D., Regitz-Zagrosek V., Scheffold T., Wachter R., Gelbrich G., Wasem J., Neumann A. & on behalf of the German Competence Network Heart Failure: Economic burden of patients with various etiologies of chronic systolic heart failure analyzed by resource use and costs. Int J Cardiol 2012;156:323-5
  • Guo W., Schafer S., Greaser M.L., Radke M.H., Liss M., Govindarajan T., Maatz H., Schulz H., Li S., Parrish A.M., Dauksaite V., Vakeel P., Klaassen S., Gerull B., Thierfelder L., Regitz-Zagrosek V., Hacker T.A., Saupe K.W., Dec G.W., Ellinor P.T., MacRae C.A., Spallek B., Fischer R., Perrot A., Özcelik C., Saar K., Hubner N. & Gotthardt M.: RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med 2012;18:766-73
  • Hall M. European Perspectives in Cardiology, Pioneer: Vera Regitz-Zagrosek, MD, PhD - Creating Awareness in Clinical Cardiology and Cardiovascular Research That "Women Are Not Just Small Men". Circulation 2012, 125:f43-f48. doi: 10.1161/CIR.0b013e31824eee98
  • Kararigas G., Bito V., Tinel H., Becher E., Baczko I., Knosalla C., Albrecht-Küpper B., Sipido K.R. & Regitz-Zagrosek V.: Transcriptome characterization of estrogen-treated human myocardium identifies myosin regulatory light chain interacting protein as a sex-specific element influencing contractile function. J Am Coll Cardiol 2012;59:410-7
  • Karlstaedt A., Fliegner D., Kararigas G., Ruderisch H.S., Regitz-Zagrosek V. & Holzhütter H.G.: CardioNet: a human metabolic network suited for the study of cardiomyocyte metabolism. BMC Syst Biol 2012;6:114
  • Lehmkuhl E., Kendel F., Gelbrich G., Dunkel A., Oertelt-Prigione S., Babitsch B., Knosalla C., Bairey-Merz N., Hetzer R. & Regitz-Zagrosek V.: Gender-specific predictors of early mortality after coronary artery bypass graft surgery. Clin Res Cardiol 2012;101:745-51
  • Li J., Umar S., Amjedi M., Iorga A., Sharma S., Nadadur R.D., Regitz-Zagrosek V. & Eghbali M.: New frontiers in heart hypertrophy during pregnancy. Am J Cardiovasc Dis 2012;2:192-207
  • Li J., Umar S., Iorga A., Youn J.Y., Wang Y., Regitz-Zagrosek V., Cai H. & Eghbali M.: Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy. Basic Res Cardiol 2012;107:271
  • Lossnitzer N, Herzog W, Stork S, Wild B, Muller-Tasch T, Lehmkuhl E, Zugck C, Regitz-Zagrosek V, Pankuweit S, Maisch B, Ertl G, Gelbrich G, Angermann CE, Competence Network Heart F. Incidence rates and predictors of major and minor depression in patients with heart failure. International journal of cardiology. 2013;167:502-507
  • Mahmoodzadeh S., Fliegner D. & Dworatzek E.: Sex differences in animal models for cardiovascular diseases and the role of estrogen. Handb Exp Pharmacol 2012;214:23-48
  • Mahmoodzadeh S., Pham T.H., Kuehne A., Fielitz B., Dworatzek E., Kararigas G., Petrov G., Davidson M.M. & Regitz-Zagrosek V.: 17?-Estradiol-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes. Cardiovasc Res 2012;96:411-21
  • Nguyen B.T., Kararigas G., Wuttke W. & Jarry H.: Long-term treatment of ovariectomized mice with estradiol or phytoestrogens as a new model to study the role of estrogenic substances in the heart. Planta Med 2012;78:6-11
  • Oertelt-Prigione S.: The influence of sex and gender on the immune response. Autoimmun Rev 2012;11:A479-85
  • Oertelt-Prigione S.: Immunology and the menstrual cycle. Autoimmun Rev 2012;11:A486-92
  • Peters W., Drueppel V., Kusche-Vihrog K., Schubert C. & Oberleithner H.: Nanomechanics and sodium permeability of endothelial surface layer modulated by hawthorn extract WS 1442. PLoS ONE 2012;7:e29972
  • Potapov E., Schweiger M., Lehmkuhl E., Vierecke J., Stepanenko A., Weng G., Pasic M., Huebler M., Regitz-Zagrosek V., Hetzer R. & Krabatsch T.: Gender differences during mechanical circulatory support. ASAIO J 2012;58:320-5
  • Regitz-Zagrosek V. Sex and gender differences in health. Science & society series on sex and science. EMBO reports. 2012;13:596-603
  • Regitz-Zagrosek V, Dworatzek E, Kintscher U, Dragun D. Sex and sex hormone-dependent cardiovascular stress responses. Hypertension. 2013;61:270-277
  • Regitz-Zagrosek V, Seeland U. Sex and gender differences in clinical medicine. Handbook of experimental pharmacology. 2012:3-22
  • Schrezenmeier E., Zollmann F.S., Seidel K., Böhm C., Schmerbach K., Kroh M., Kirsch S., Klare S., Bernhard S., Kappert K., Goldin-Lang P., Skuballa W., Unger T. & Funke-Kaiser H.: Moderate correlations of in vitro versus in vivo pharmacokinetics questioning the need of early microsomal stability testing. Pharmacology 2012;90:307-15
  • Schuld J., Richter S., Oberkircher L.W.W., Seeland U., Debnar-Daumler K.I., Rauch J., Menger M.D., Schilling M.K. & Kollmar O.: Evidence for tumor cell spread during local hepatic ablation of colorectal liver metastases. J Surg Res 2012;178:268-79
  • Seeland U., Goldin-Lang P. & Regitz-Zagrosek V.: [Cardiovascular diseases in pregnancy: facts of the new guideline]. Deut Med Wochenschr 2012;137:1568-72
  • Seeland U. & Regitz-Zagrosek V.: Sex and gender differences in cardiovascular drug therapy.
  • Handb Exp Pharmacol 2012;214:211-36
  • Viegas V.U., Liu Z.Z., Nikitina T., Perlewitz A., Zavaritskaya O., Schlichting J., Persson P.B., Regitz-Zagrosek V., Patzak A. & Sendeski M.M.: Angiotensin II type 2 receptor mediates sex differences in mice renal interlobar arteries response to angiotensin II. J Hypertens 2012;30:1791-8
  • Westphal C., Schubert C., Prelle K., Penkalla A., Fliegner D., Petrov G. & Regitz-Zagrosek V.: Effects of estrogen, an ERα agonist and raloxifene on pressure overload induced cardiac hypertrophy. PLoS ONE 2012;7:e50802
  • Zugck C., Franke J., Gelbrich G., Frankenstein L., Scheffold T., Pankuweit S., Duengen H.D., Regitz-Zagrosek V., Pieske B., Neumann T., Rauchhaus M., Angermann C.E., Katus H.A., Ertl G.E. & Störk S.: Implementation of pharmacotherapy guidelines in heart failure: experience from the German Competence Network Heart Failure. Clin Res Cardiol 2012;101:263-72

Publikationen 2011

  • Regitz-Zagrosek V, et al "ESC guidelines on the management of cardiovascular diseases during pregnancy" Eur Heart J 2011; DOI: 10.1093/eurheartj/ehr218.
  • Waldmüller S, Erdmann J, Binner P, Gelbrich G, Pankuweit S, Geier C, Timmermann B, Haremza J, Perrot A, Scheer S, Wachter R, Schulze-Waltrup N, Dermintzoglou A, Schönberger J, Zeh W, Jurmann B, Brodherr T, Börgel J, Farr M, Milting H, Blankenfeldt W, Reinhardt R, Ozcelik C, Osterziel KJ, Loeffler M, Maisch B, Regitz-Zagrosek V, Schunkert H, Scheffold T; on behalf of the German Competence Network Heart Failure. Novel correlations between the genotype and the phenotype of hypertrophic and dilated cardiomyopathy: results from the German Competence Network Heart Failure. Eur J Heart Fail. 2011 Jul 12. [Epub ahead of print] PubMed PMID: 21750094.
  • Eggeling T, Regitz-Zagrosek V, Zimmermann A, Burkart M. Baseline severity but not gender modulates quantified Crataegus extract effects in early heart failure - A pooled analysis of clinical trials. Phytomedicine. 2011 Jul 22. [Epub ahead of print] PubMed PMID: 21784624.
  • Regitz-Zagrosek V, Seeland U, Geibel-Zehender A, Gohlke-Bärwolf C, Kruck I, Schaefer C. Cardiovascular diseases in pregnancy. Dtsch Arztebl Int. 2011 Apr;108(16):267-73. Epub 2011 Apr 22. PubMed PMID: 21603561; PubMed Central PMCID: PMC3097487.
  • Foryst-Ludwig A, Kreissl MC, Sprang C, Thalke B, Böhm C, Benz V, Gürgen D, Dragun D, Schubert C, Mai K, Stawowy P, Spranger J, Regitz-Zagrosek V, Unger T, Kintscher U. Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability. Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H115-22. Epub 2011 Apr 8. PubMed PMID: 21478409.
  • Regitz-Zagrosek V, Seeland U. Sex and gender differences in myocardial hypertrophy and heart failure. Wien Med Wochenschr. 2011 Mar;161(5-6):109-16. PubMed PMID: 21461800.
  • Villard E, Perret C, Gary F, Proust C, Dilanian G, Hengstenberg C, Ruppert V, Arbustini E, Wichter T, Germain M, Dubourg O, Tavazzi L, Aumont MC, DeGroote P, Fauchier L, Trochu JN, Gibelin P, Aupetit JF, Stark K, Erdmann J, Hetzer R, Roberts AM, Barton PJ, Regitz-Zagrosek V; Cardiogenics Consortium, Aslam U, Duboscq-Bidot L, Meyborg M, Maisch B, Madeira H, Waldenström A, Galve E, Cleland JG, Dorent R, Roizes G, Zeller T, Blankenberg S, Goodall AH, Cook S, Tregouet DA, Tiret L, Isnard R, Komajda M, Charron P, Cambien F. A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. Eur Heart J. 2011 May;32(9):1065-76. Epub 2011 Apr 1. PubMed PMID: 21459883; PubMed Central PMCID: PMC3086901.
  • Edelmann F, Stahrenberg R, Gelbrich G, Durstewitz K, Angermann CE, Düngen HD, Scheffold T, Zugck C, Maisch B, Regitz-Zagrosek V, Hasenfuß G, Pieske BM, Wachter R. Contribution of comorbidities to functional impairment is higher in heart failure with preserved than with reduced ejection fraction. Clin Res Cardiol. 2011 Mar 17. [Epub ahead of print] PubMed PMID: 21416189.
  • Maas AH, van der Schouw YT, Regitz-Zagrosek V, Swahn E, Appelman YE, Pasterkamp G, Ten Cate H, Nilsson PM, Huisman MV, Stam HC, Eizema K, Stramba-Badiale M. Red alert for women's heart: the urgent need for more research and knowledge on cardiovascular disease in women: proceedings of the workshop held in Brussels on gender differences in cardiovascular disease, 29 September 2010. Eur Heart J. 2011 Jun;32(11):1362-8. Epub 2011 Mar 15. PubMed PMID: 21406440.
  • Kendel F, Dunkel A, Müller-Tasch T, Steinberg K, Lehmkuhl E, Hetzer R, Regitz-Zagrosek V. Gender differences in health-related quality of life after coronary bypass surgery: results from a 1-year follow-up in propensity-matched men and women. Psychosom Med. 2011 Apr;73(3):280-5. Epub 2011 Mar 1. PubMed PMID: 21364199.
  • Kararigas G, Fliegner D, Gustafsson JÅ, Regitz-Zagrosek V. Role of the estrogen/estrogen-receptor-beta axis in the genomic response to pressure overload-induced hypertrophy. Physiol Genomics. 2011 Apr 27;43(8):438-46. Epub 2011 Feb 15. PubMed PMID: 21325064.
  • Dunkel A, Kendel F, Lehmkuhl E, Hetzer R, Regitz-Zagrosek V. Causal attributions among patients undergoing coronary artery bypass surgery: gender aspects and relation to depressive symptomatology. J Behav Med. 2011 Feb 9. [Epub ahead of print] PubMed PMID: 21305349.
  • Oertelt-Prigione S, Wiedmann S, Endres M, Nolte CH, Regitz-Zagrosek V, Heuschmann P. Stroke and myocardial infarction: a comparative systematic evaluation of gender-specific analysis, funding and authorship patterns in cardiovascular research. Cerebrovasc Dis. 2011;31(4):373-81. Epub 2011 Jan 19. Review. PubMed PMID: 21252506.

Publikationen 2010

  • Kararigas G, Becher E, Mahmoodzadeh S, Knosalla C, Hetzer R, Regitz-Zagrosek V. Sex-specific modification of progesterone receptor expression by 17β-oestradiol in human cardiac tissues. Biol Sex Differ. 2010 Nov 4;1(1):2. PubMed PMID: 21208464; PubMed Central PMCID: PMC3010101.
  • Oertelt-Prigione S, Parol R, Krohn S, Preissner R, Regitz-Zagrosek V. Analysis of sex and gender-specific research reveals a common increase in publications and marked differences between disciplines. BMC Med. 2010 Nov 10;8:70. PubMed PMID: 21067576; PubMed Central PMCID: PMC2993643.
  • Stark K, Esslinger UB, Reinhard W, et al. Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathy. PLoS Genet. 2010 Oct 21;6(10):e1001167. PubMed PMID: 20975947; PubMed Central PMCID: PMC2958814.
  • Kendel F, Gelbrich G, Wirtz M, Lehmkuhl E, Knoll N, Hetzer R, Regitz-Zagrosek V. Predictive relationship between depression and physical functioning after coronary surgery. Arch Intern Med. 2010 Oct 25;170(19):1717-21. PubMed PMID: 20975017.
  • Petrov G, Regitz-Zagrosek V, Lehmkuhl E, Krabatsch T, Dunkel A, Dandel M, Dworatzek E, Mahmoodzadeh S, Schubert C, Becher E, Hampl H, Hetzer R. Regression of myocardial hypertrophy after aortic valve replacement: faster in women? Circulation. 2010 Sep 14;122(11 Suppl):S23-8. PubMed PMID: 20837918.
  • Toischer K, Rokita AG, Unsöld B, et al. Differential cardiac remodeling in preload versus afterload. Circulation. 2010 Sep 7;122(10):993-1003. Epub 2010 Aug 23. PubMed PMID:20733099; PubMed Central PMCID: PMC2955196.
  • Sliwa K, Hilfiker-Kleiner D, Petrie MC, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. Eur J Heart Fail. 2010 Aug;12(8):767-78. Review. PubMed PMID:20675664.

Publikationen 2009

  • Mahmoodzadeh S, Dworatzek E, Fritschka S, Pham TH, Regitz-Zagrosek V.17{beta}-estradiol inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts. Cardiovasc Res. 2009 Nov 19.
  • Oertelt-Prigione S, Regitz-Zagrosek V.Women's cardiovascular health: prevention is key.Arch Intern Med. 2009 Oct 26;169(19):1740-1.
  • Mahmoodzadeh S, Fritschka S, Dworatzek E, et al. Nuclear factor-Kappa B regulates estrogen receptor-alpha transcription in the human heart. J Biol Chem 2009; (in press).
  • Kendel F, Wirtz M, Dunkel A, Lehmkuhl E, Hetzer R, Regitz-Zagrosek V. Screening for depression: Rasch analysis of the dimensional structure of the 3 PHQ-9 and the HADS-D. Journal of Affective Disorders 2009; (in press).
  • Dunkel A, Regitz-Zagrosek V. Predictors of preoperative depressive risk in patients undergoing coronary artery bypass graft (CABG) surgery. Clin Res Cardiol 2009; (in press).
  • Oertelt-Prigione S, Regitz-Zagrosek V. Gender Aspects in Cardiovascular Pharmacology. J Cardiovasc Transl Res. (in press)
  • Friedrichs F, Zugck C, Rauch GJ, et al. HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Genome Res 2009; 19 (3): 395.
  • Boengler K, Buschmann I, Deindl E, et al. On the occasion of Wolfgang Schaper's 75th birthday. Basic Res Cardiol 2009; 104 (1): 2.

Publikationen 2008

  • Gohlke-Barwolf C, Pildner von Steinburg S, Kaemmerer H, Regitz-Zagrosek, V. [Anticoagulation and thrombophilia in pregnancy]. Internist (Berl). Jul 2008;49(7):779-787.
  • Isensee J, Witt H, Pregla R, Hetzer R, Regitz-Zagrosek V, Ruiz Noppinger P. Sexually dimorphic gene expression in the heart of mice and men. J Mol Med. Jan 2008;86(1):61-74.
  • Karatas A, Hegner B, de Windt LJ, Luft FC, Schubert C, Gross V, Akashi YJ, Gurgen D, Kintscher U, da Costa Goncalves AC, Regitz-Zagrosek V, Dragun D. Deoxycorticosterone acetate-salt mice exhibit blood pressure-independent sexual dimorphism. Hypertension. Apr 2008;51(4):1177-1183.
  • Regitz-Zagrosek V, Schubert C. [Sex differences in cardiovascular drug targeting.]. Internist (Berl). Nov 2008;49(11):1383-1390.
  • Regitz-Zagrosek V, Lehmkuhl E, Lehmkuhl HB. [Heart failure--are there gender aspects?]. Internist (Berl). Apr 2008;49(4):422-426, 428.
  • Regitz-Zagrosek V, Schubert C, Kruger S. [Gender differences in psychopharmacology.]. Internist (Berl). Oct 29 2008.
  • Regitz-Zagrosek V, Gohlke-Barwolf C, Geibel-Zehender A, Haass M, Kaemmerer H, Kruck I, Nienaber C. Herzerkrankungen in der Schwangerschaft. Clin Res Cardiol. Sep 2008;97(9):630-665
  • Witt H, Schubert C, Jaekel J, Fliegner D, Penkalla A, Tiemann K, Stypmann J, Roepcke S, Brokat S, Mahmoodzadeh S, Brozova E, Davidson MM, Ruiz Noppinger P, Grohé C, Regitz-Zagrosek V. Sex-specific pathways in early cardiac response to pressure overload in mice. J Mol Med. Sep 2008;86(9):1013-1024.

Publikationen 2007

  • Diedrich M, Tadic J, Mao L, Wacker M A, Nebrich G, Hetzer R, Regitz-Zagrosek V, Klose J. Heart protein expression related to age and sex in mice and humans. Int J Mol Med. Dec 2007;20(6):865-874.
  • Lehmkuhl E, Regitz-Zagrosek V. [Implications of gender-specific aspects in the therapy of cardiovascular diseases]. Ther Umsch. Jun 2007;64(6):311-317.
  • Regitz-Zagrosek V, Brokat S, Tschope C. Role of gender in heart failure with normal left ventricular ejection fraction. Prog Cardiovasc Dis. Jan-Feb 2007;49(4):241-251.
  • Regitz-Zagrosek V, Lehmkuhl E, Mahmoodzadeh S. Gender aspects of the role of the metabolic syndrome as a risk factor for cardiovascular disease. Gend Med. 2007;4 Suppl B:S162-177.

Publikationen 2006

  • Gong LJ, Lehmkuhl E, Hu SS, Kendel F, Kandle S, Du Y, Zhang Y, Du M, Wu QY, Xu JP, Sun LZ, Zhu XD, Regitz-Zagrosek V. [Impact of gender and age on in-hospital mortality after coronary artery bypass graft]. Zhonghua Xin Xue Guan Bing Za Zhi. May 2006;34(5):415-421.
  • Regitz-Zagrosek V. Therapeutic implications of the gender-specific aspects of cardiovascu-lar disease. Nat Rev Drug Discov. May 2006;5(5):425-438.
  • Regitz-Zagrosek V, Lehmkuhl E, Weickert MO. Gender differences in the metabolic syn-drome and their role for cardiovascular disease. Clin Res Cardiol. Mar 2006;95(3):136-147.