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GendAge - Sex- and gendersensitive prevention of cardiovascular and metabolic diseases in older adults in Germany

Funding: BMBF
2017 until 2021
Project Leader: PD Dr. Ilja Demuth, Charité (Interdisciplinary Metabolism Centre)

Partners: Charité (GiM), Humboldt-Universität

The GendAge Project aims to understand which mechanisms affect cardio-metabolic morbidity, mortality, and quality of life among older adults in a sex- and gender-sensitive manner. Our goal is to include the sociocultural construct gender for the first time in a large-scale comprehensive German study and develop a novel construct for gender. We will analyze, which mechanisms must be targeted to reduce the development of manifest disease endpoints from intermediate phenotypes in a sex- and gender-sensitive manner. The study is based on the 1600 older women and men of the existing Berlin Aging Study II (BASE-II) that comprehensibly extracted variables from the fields of cardiovascular and metabolic health, socio-economics and Quality of Life.

Furthermore, the extraction of follow-up data (as part of the planned investigation) will allow for longitudinal analyses of pathogenesis, disease conditions, as well as the underlying factors. An important step in the investigation is to understand the role of gender, in addition to sex, in relation to the Analysis of cardiovascular risk factors and diseases. In order to achieve this, we will develop a new measure for gender that is based on traditional gender stereotypes, that will be validated and tested for its application.