Oxidative stress is a deciding factor in many cardiovascular diseases and is caused by free radicals. These highly aggressive molecules are produced by the body through metabolic exchanges or external influences. Reactive Oxygen species are of particular importance for research in this context. The main aim of the RADOX Project is to investigate the influences of these radicals on cardiovascular diseases. The results will contribute to the development of new diagnostics and therapy strategies.

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RADOX- RADical reduction of OXidative stress in cardiovasular diseases

EU (FP7-PEOPLE-2012-ITN; GA 316738),

Coordinator Charité-Universitätsmedizin Berlin

PI: Vera Regitz-Zagrosek, 2013-2016 Partner: Keith Channon (University of Oxford, United Kingdom), Thomas Krieg (University of Cambridge, United Kingdom), Rhian Touyz (University of Glasgow, United Kingdom), Stefan Janssens (University of Leuven, Belgium), Fabio di Lisa (University of Padua, Italy), Guillermo Zalba (University of Navarra, Pamplona, Spain), Barbara Albrech-Küppers/Tobias Marquardt (Bayer Wuppertal, Germany), Uli Schotten (University of Maastricht, Netherlands)

Cardiovascular diseases (CVD) constitute a major and increasing health and ensuing economic burden in developed countries. The prediction is that the prevalence of these conditions will increase by ~60% over the next 20 years. Subsequently the development of novel treatments for patients with CVD becomes more and more urgent. Oxidative stress is a major molecular contributor to the pathogenesis of CVD; however, oxidative stress related therapeutic strategies are still missing. The RADOX consortium linked excellent investigators highly active in the field of oxidative stress-signaling, and strongly enhanced collaborative research and integrated complementary interests to obtain innovative science and outstanding in-depth integrative multidisciplinary training possibilities. This RADOX consortium consisted of 9 full partners (8 academic and 1 private) and 4 associate private partners and trained at the end 15 PhD-students, and 4 junior post doctoral fellows. The mission of this ITN-project was to create future leaders in the field of redox and oxidative stress-biology and to lay the foundation for a robust translational research and training program in this field. Specifically, we aimed to characterize the specific sources of reactive oxygen species (ROS) and their interaction in cardiovascular disease and to use this knowledge to develop diagnostic tools for the detection and quantification of ROS and their subcellular targets. We wanted to build a basis for the development of new therapeutic strategies which modulate the activity of these specific sources of ROS. Therefore, the project objectives also complied perfectly with the FP7 focus on identification and validation of novel, therapeutically relevant targets for the development of new medications for cardiovascular pathologies.