Dr. rer. nat. Yury Ladilov


Charité – Universitätsmedizin Berlin
Hessische Str. 3-4
10115 Berlin

Campus / internal address:
Hessische Str. 3-4

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Additional information

Selected Publications

Ma N, Ladilov Y, Moebius JM, Ong L, Piechaczek C, Dávid A, Kaminski A, Choi YH, Li W, Egger D, Stamm C, Steinhoff G. Intramyocardial delivery of human CD133+ cells in a SCID mouse cryoinjury model: Bone marrow vs. cord blood-derived cells. Cardiovasc Res. 2006, 71:158-69.

Zhang L, Kumar S, Kaminski A, Kasch C, Sponholz C, Stamm C, Ladilov Y, Steinhoff G. Importance of endothelial nitric oxide synthase for the hypothermic protection of lungs against ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2006, 131:969-74.

Ma N, Ladilov Y, Kaminski A, Piechaczek C, Choi YH, Li W, Steinhoff G, Stamm C. Umbilical cord blood cell transplantation for myocardial regeneration. Transplant Proc. 2006, 38:771-3.

Kaminski A, Kasch C, Zhang L, Kumar S, Sponholz C, Choi YH, Ma N, Liebold A, Ladilov Y, Steinhoff G, Stamm C. Endothelial nitric oxide synthase mediates protective effects of hypoxic preconditioning in lungs. Respir Physiol Neurobiol 2007, 155:280-5.

Li W, Ma N, Ong LL, Nesselmann C, Klopsch C, Ladilov Y, Furlani D, Piechaczek C, Moebius JM, Lutzow K, Lendlein A, Stamm C, Li RK, Steinhoff G. Bcl-2 Engineered MSCs inhibited apoptosis and improved heart function. Stem Cells 2007, 25: 2118-27.

Kumar S, Kasseckert S, Kostin S, Abdallah Y, Schafer C, Kaminski A, Reusch HP, Piper HM, Steinhoff G, Ladilov Y. Ischemic acidosis causes apoptosis in coronary endothelial cells through activation of caspase-12. Cardiovasc Res 2007, 73:172-80.

Kumar S, Kasseckert S, Kostin S, Abdallah Y, Piper HM, Steinhoff G, Reusch HP, Ladilov Y. Importance of bicarbonate transport for ischaemia-induced apoptosis of coronary endothelial cells. J Cell Mol Med 2007, 11:798-809.

Kumar S, Reusch HP, Ladilov Y. Acidic pre-conditioning suppresses apoptosis and increases expression of Bcl-xL in coronary endothelial cells under simulated ischaemia. J Cell Mol Med 2008, 12:1584-92.

Flacke JP, Kumar S, Kostin S, Reusch HP, Ladilov Y. Acidic preconditioning protects endothelial cells against Apoptosis through p38- and Akt-dependent Bcl-xL overexpression. Apoptosis 2009, 14:90-6.

Kumar S, Kostin S, Flacke JP, Reusch HP, Ladilov Y. Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. J Biol Chem 2009, 284: 14760-14768.

Abdallah Y, Wolf C, Meuter K, Piper HM, Reusch HP, Ladilov Y. Preconditioning with diazoxide prevents reoxygenation-induced rigor-type hypercontracture. J Mol Cell Cardiol. 2010, 48:270-6.

Abdallah Y, Iraqi W, Said M, Kasseckert SA, Shahzad T, Erdogan A, Neuhof C, Gündüz D, Schlüter KD, Piper HM, Reusch HP, Ladilov Y. Interplay between Ca(2+) cycling and mitochondrial permeability transition pores promotes reperfusion-induced injury of cardiac myocytes. J Cell Mol Med. 2011 15:2478-85.

Kumar S, Flacke JP, Kostin S, Appukuttan A, Reusch HP, Ladilov Y. SLC4A7 sodium bicarbonate co-transporter controls mitochondrial apoptosis in ischaemic coronary endothelial cells. Cardiovasc Res. 2011, 89:392-400.

Appukuttan A, Kasseckert SA, Micoogullari M, Flacke JP, Kumar S, Woste A, Abdallah Y, Pott L, Reusch HP, Ladilov Y. Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischemia/reperfusion. Cardiovasc Res 2012, 93:340-9.

Ladilov Y. Preconditioning with hypercapnic acidosis: Hope for the ischemic brain. Neurosci Lett. 2012, 523:1-2.

Flacke JP, Flacke H, Appukuttan A, Palisaar RJ, Noldus J, Robinson BD, Reusch HP, Zippin JH, Ladilov Y. Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells. J Biol Chem. 2013, 288:3126-35.

Shahzad T, Kasseckert S, Iraqi W, Johnson V, Schulz S, Schlüter KD, Dörr O, Parahuleva M, Ladilov Y, Abdallah Y. Mechanisms involved in postconditioning protection of cardiomyocytes against acute reperfusion injury. J Mol Cell Cardiol. 2013;58:209-16

Appukuttan A, Kasseckert SA, Kumar S, Reusch HP, Ladilov Y. Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase. Cardiovasc Res. 2013; 99:734-42.

Kumar S, Appukuttan A, Maghnouj A, Hahn S, Peter Reusch H, Ladilov Y. Suppression of soluble adenylyl cyclase protects smooth muscle cells against oxidative stress-induced apoptosis. Apoptosis. 2014; 19:1069-79.

Appukuttan A, Flacke JP, Flacke A, Posadovskyi A, Reusch HP, Ladilov Y. Inhibition of soluble adenylyl cyclase increases the radiosensitivity of prostate cancer cells. Biochim Biophys Acta-Mol Basis Dis 2014; 1842:2656-63

Read DE, Gupta A, Ladilov Y, Samali A, Gupta S. miRNA signature of unfolded protein response in H9C2 rat cardiomyoblasts. Cell Biosci. 2014; 4:56.

Ladilov Y, Appukuttan A. Role of soluble adenylyl cyclase in cell death and growth. Biochim Biophys Acta-Mol Basis Dis 2014; 1842:2646-55.

Schirmera I, Bualeong T, Appukuttan A, Cimiotti D, Steinwascher P, Reusch P, Mügge A , Meyer R, Ladilov Y, Jaquet K. Soluble adenylyl cyclase: a new player in cardiac hypertrophy induced by isoprenaline and pressure overload. 2016 (in revision).

Vita Dr. rer. nat. Yury Ladilov

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