Prof. Dr. rer. nat Georgios Kararigas

DZHK Professor

Charité – Universitätsmedizin Berlin
Hessische Str. 3-4
10115 Berlin

Campus / internal address:
Hessische Str. 3-4

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Research interests

His primary research interests include mechanisms of sex differences in cardiovascular (patho)physiology, hormonal effects in the heart, gene expression and regulation. In particular, he focuses on the analysis of heart-specific regulatory functions of oestrogen using a combination of computational and genome-wide methods, in vitro and in vivo models, in animals and human-derived material, and the effects of sex on these. His goal is the development of novel therapies for heart failure.

Vita Prof. Dr. rer. nat Georgios Kararigas

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Selected Publications

Lai S, Collins BC, Colson BA, Kararigas G, Lowe DA. Estradiol modulates myosin regulatory light chain phosphorylation and contractility in skeletal muscle of female mice. Am J Physiol Endocrinol Metab 2016;310(9):E724-33

Dworatzek E, Baczko I, Kararigas G. Effects of aging on cardiac extracellular matrix in men and women. Proteomics Clin Appl 2016;10(1):84-91

Kararigas G, Fliegner D, Forler S, Klein O, Schubert C, Klose J, Regitz-Zagrosek V. Comparative proteomic analysis reveals sex and estrogen receptor β effects in the pressure overloaded heart. J Proteome Res 2014;13(12):5829-36

Kararigas G, Dworatzek E, Petrov G, Summer H, Schulze TM, Baczko I, Knosalla C, Golz S, Hetzer R, Regitz-Zagrosek V. Sex-dependent regulation of fibrosis and inflammation in human left ventricular remodelling under pressure overload. Eur J Heart Fail 2014;16(11):1160-7

Kararigas G, Nguyen BT, Zelarayan LC, Hassenpflug M, Toischer K, Sanchez-Ruderisch H, Hasenfuss G, Bergmann MW, Jarry H, Regitz-Zagrosek V. Genetic background defines the regulation of postnatal cardiac growth by 17β-estradiol through a β-catenin mechanism. Endocrinology 2014;155(7):2667-76

Kararigas G, Nguyen BT, Jarry H. Estrogen modulates cardiac growth through an estrogen receptor α-dependent mechanism in healthy ovariectomized mice. Mol Cell Endocrinol 2014;382(2):909-14

Karlstaedt A, Fliegner D, Kararigas G, Ruderisch HS, Regitz-Zagrosek V, Holzhütter HG. CardioNet: A human metabolic network suited for the study of cardiomyocyte metabolism. BMC Syst Biol 2012;6(1):114

Kararigas G, Bito V, Tinel H, Becher E, Baczko I, Knosalla C, Albrecht B, Sipido KR, Regitz-Zagrosek V. Transcriptome characterization of estrogen-treated human myocardium identifies myosin regulatory light chain interacting protein as a sex-specific element influencing contractile function. J Am Coll Cardiol 2012;59(4):410-7

Kararigas G, Fliegner D, Gustafsson JA, Regitz-Zagrosek V. Role of the estrogen/estrogen-receptor-beta axis in the genomic response to pressure overload-induced hypertrophy. Physiol Genomics 2011;43(8):438-46

Kararigas G, Becher E, Mahmoodzadeh S, Knosalla C, Hetzer R, Regitz-Zagrosek V. Sex-specific modification of progesterone